Linker Information
General Information of This Linker
| Linker ID |
LIN0SOAEA
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| Linker Name |
Maleimidyl-PEG2-Val-Cit-pAB linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C29H42N6O9
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| Isosmiles |
CC([C@H](NC(CCOCCOCCN1C(C=CC1=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(CO)C=C2)=O)=O)C
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| PubChem CID | ||||||
| InChI |
InChI=1S/C29H42N6O9/c1-19(2)26(34-23(37)11-14-43-16-17-44-15-13-35-24(38)9-10-25(35)39)28(41)33-22(4-3-12-31-29(30)42)27(40)32-21-7-5-20(18-36)6-8-21/h5-10,19,22,26,36H,3-4,11-18H2,1-2H3,(H,32,40)(H,33,41)(H,34,37)(H3,30,31,42)/t22-,26-/m0/s1
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| InChIKey |
NXGJAGHMGZCZSF-NVQXNPDNSA-N
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| Pharmaceutical Properties |
Molecule Weight
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618.688
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Polar area
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218.49
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Complexity
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1099.074443
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xlogp Value
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-0.4602
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Heavy Count
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44
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Rot Bonds
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20
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Hbond acc
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9
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
MORAb-003 ADC7 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | High FRA expression (FRA +++) | ||
| Method Description |
Use crystal violet analysis to evaluate the in vitro efficacy of the prepared ADCs. Initially screen all MORAb003 ADCs on IGROV1 (FRi (+++)) and SJSA - 1 (FReg (-)) cells.
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| In Vitro Model | Osteosarcoma | SJSA-1 cells | CVCL_1697 | ||