Linker Information
General Information of This Linker
| Linker ID |
LIN0SHCUT
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| Linker Name |
Aminobenzazepine-linker Formula II-5
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C79H133F4N5O34
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| Isosmiles |
CC(C)[C@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(OC1=C(F)C(F)=CC(F)=C1F)=O)=O)C(N[C@H](C(NC2=CC=C(COC(O)=O)C=C2)=O)CCCNC(N)=O)=O
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| InChI |
InChI=1S/C79H133F4N5O34/c1-64(2)74(77(92)87-69(4-3-11-85-78(84)93)76(91)86-66-7-5-65(6-8-66)63-121-79(94)95)88-70(89)9-12-96-14-16-98-18-20-100-22-24-102-26-28-104-30-32-106-34-36-108-38-40-110-42-44-112-46-48-114-50-52-116-54-56-118-58-60-120-61-59-119-57-55-117-53-51-115-49-47-113-45-43-111-41-39-109-37-35-107-33-31-105-29-27-103-25-23-101-21-19-99-17-15-97-13-10-71(90)122-75-72(82)67(80)62-68(81)73(75)83/h5-8,62,64,69,74H,3-4,9-61,63H2,1-2H3,(H,86,91)(H,87,92)(H,88,89)(H,94,95)(H3,84,85,93)/t69-,74-/m0/s1
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| InChIKey |
HTRHSABFRJHWSV-FSPCZXLBSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1772.926
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Polar area
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446
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Complexity
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.
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xlogp Value
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3.251
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Heavy Count
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122
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Rot Bonds
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91
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Hbond acc
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33
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2020291014A1 IC-4 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||