Linker Information
General Information of This Linker
| Linker ID |
LIN0SFQKB
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| Linker Name |
Solubilizing group-PEG0-Hypoxia sensitive linker-Azobenzene
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| Linker Type |
Hypoxia sensitive linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C26H28N6O6
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| Isosmiles |
OCC1=CC=C(/N=N/C(C=C2)=CC=C2C(NCCNC(CCNC(CCN3C(C=CC3=O)=O)=O)=O)=O)C=C1
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| InChI |
InChI=1S/C26H28N6O6/c33-17-18-1-5-20(6-2-18)30-31-21-7-3-19(4-8-21)26(38)29-15-14-28-22(34)11-13-27-23(35)12-16-32-24(36)9-10-25(32)37/h1-10,33H,11-17H2,(H,27,35)(H,28,34)(H,29,38)/b31-30+
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| InChIKey |
ALLZRXVKHXRLCZ-NVQSTNCTSA-N
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| Pharmaceutical Properties |
Molecule Weight
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520.546
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Polar area
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169.63
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Complexity
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1159.604352
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xlogp Value
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1.2617
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Heavy Count
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38
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Rot Bonds
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13
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Hbond acc
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8
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
aZO-ADC-0 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.063 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to SKOV-3 cells under 0.1 % O2
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| In Vitro Model | Ovarian serous adenocarcinoma | SKOV-3 cells | CVCL_0532 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.19 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to BT474-HDR cells under 0.1 % O2
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| In Vitro Model | Invasive breast carcinoma of no special type | BT474-HDR cells | CVCL_0179 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
66.8 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 to SKOV-3 cells under 20 % O2
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| In Vitro Model | Ovarian serous adenocarcinoma | SKOV-3 cells | CVCL_0532 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
109.1 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of AZO-ADC-0/4/6/8 toBT474-HDR cells under 20 % O2
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| In Vitro Model | Invasive breast carcinoma of no special type | BT474-HDR cells | CVCL_0179 | ||
References