Linker Information
General Information of This Linker
| Linker ID |
LIN0SETHK
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|---|---|---|---|---|---|---|
| Linker Name |
Drug linker PB039
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C67H118N6O29
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| Isosmiles |
CC([C@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(N[C@@H](CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)C(NC2=CC=C(C=C2)CO)=O)=O)C
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| InChI |
InChI=1S/C67H118N6O29/c1-49(2)61(71-58(82)9-4-3-7-18-73-59(83)14-15-60(73)84)67(90)70-52(66(89)69-51-12-10-50(46-74)11-13-51)8-5-6-17-68-57(81)16-20-91-22-24-93-26-28-95-30-32-97-34-36-99-38-40-101-42-43-102-41-39-100-37-35-98-33-31-96-29-27-94-25-23-92-21-19-72(44-53(77)62(85)64(87)55(79)47-75)45-54(78)63(86)65(88)56(80)48-76/h10-15,49,52-56,61-65,74-80,85-88H,3-9,16-48H2,1-2H3,(H,68,81)(H,69,89)(H,70,90)(H,71,82)/t52-,53-,54-,55+,56+,61-,62+,63+,64+,65+/m0/s1
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| InChIKey |
DFBAIXMGCKFWOV-YMCGKYKUSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1471.694
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Polar area
|
490.31
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Complexity
|
2192.252121
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xlogp Value
|
-4.722
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Heavy Count
|
102
|
Rot Bonds
|
69
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Hbond acc
|
30
|
Hbond Donor
|
15
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Each Antibody-drug Conjugate Related to This Linker