Linker Information
General Information of This Linker
| Linker ID |
LIN0SDTZA
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| Linker Name |
CN113874046B-ADC-7-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C50H74N12O9
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| Isosmiles |
CC([C@H](NC(C1=CC=C(NC(CCOCCOCCNC2CCN(CC2)C(CCN3C4=C(C=C3CN(NC)C)C=CC=N4)=O)=O)C=C1)=O)C(N[C@@H](CCCNC(N)=O)C(NC5=CC=C(CO)C=C5)O)=O)C
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| InChI |
InChI=1S/C50H74N12O9/c1-34(2)45(49(68)58-42(8-6-22-55-50(51)69)48(67)57-40-13-9-35(33-63)10-14-40)59-47(66)36-11-15-39(16-12-36)56-43(64)20-27-70-29-30-71-28-23-53-38-17-24-61(25-18-38)44(65)19-26-62-41(32-60(4)52-3)31-37-7-5-21-54-46(37)62/h5,7,9-16,21,31,34,38,42,45,48,52-53,57,63,67H,6,8,17-20,22-30,32-33H2,1-4H3,(H,56,64)(H,58,68)(H,59,66)(H3,51,55,69)/t42-,45-,48?/m0/s1
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| InChIKey |
ZUHGQKDMVIEVAP-ZHZORQCASA-N
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| Pharmaceutical Properties |
Molecule Weight
|
987.217
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Polar area
|
278.8
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Complexity
|
2205.091077
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xlogp Value
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2.2457
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Heavy Count
|
71
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Rot Bonds
|
30
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Hbond acc
|
15
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Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker