Linker Information
General Information of This Linker
| Linker ID |
LIN0SATZZ
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|---|---|---|---|---|---|---|
| Name |
Mal-Val-Lys-PAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C27H37N7O8
|
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| Isosmiles |
CC([C@H](NC(CNC(CCN1C(C=CC1=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(CO)C=C2)=O)=O)C
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| InChI |
InChI=1S/C27H37N7O8/c1-16(2)24(33-21(37)14-30-20(36)11-13-34-22(38)9-10-23(34)39)26(41)32-19(4-3-12-29-27(28)42)25(40)31-18-7-5-17(15-35)6-8-18/h5-10,16,19,24,35H,3-4,11-15H2,1-2H3,(H,30,36)(H,31,40)(H,32,41)(H,33,37)(H3,28,29,42)/t19-,24-/m0/s1
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| InChIKey |
XHAXINQMUABVLF-CYFREDJKSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
587.634
|
Polar area
|
229.13
|
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|
Complexity
|
1126.923654
|
xlogp Value
|
-1.3772
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Heavy Count
|
42
|
Rot Bonds
|
16
|
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|
Hbond acc
|
8
|
Hbond Donor
|
7
|
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Each Antibody-drug Conjugate Related to This Linker