Linker Information
General Information of This Linker
| Linker ID |
LIN0RRYFK
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| Linker Name |
ThioBridge®-VCP linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C97H155N7O38S2
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| Isosmiles |
CC([C@H](NC(CC[C@H](NC(C1=CC=C(C(C(CS(C(C=C2)=CC=C2C)(=O)=O)CS(C3=CC=CC=C3)(=O)=O)=O)C=C1)=O)C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)COC(O)=O)=O)=O)C
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| InChI |
InChI=1S/C97H155N7O38S2/c1-78(2)90(95(110)103-87(11-8-26-100-96(98)111)94(109)101-84-20-14-80(15-21-84)75-142-97(112)113)104-89(105)25-24-88(102-92(107)82-18-16-81(17-19-82)91(106)83(76-143(114,115)85-9-6-5-7-10-85)77-144(116,117)86-22-12-79(3)13-23-86)93(108)99-27-28-119-31-32-121-35-36-123-39-40-125-43-44-127-47-48-129-51-52-131-55-56-133-59-60-135-63-64-137-67-68-139-71-72-141-74-73-140-70-69-138-66-65-136-62-61-134-58-57-132-54-53-130-50-49-128-46-45-126-42-41-124-38-37-122-34-33-120-30-29-118-4/h5-7,9-10,12-23,78,83,87-88,90H,8,11,24-77H2,1-4H3,(H,99,108)(H,101,109)(H,102,107)(H,103,110)(H,104,105)(H,112,113)(H3,98,100,111)/t83?,87-,88-,90-/m0/s1
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| InChIKey |
CPJSCHSUQHBTQR-ZVNVFXLCSA-N
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| Pharmaceutical Properties |
Molecule Weight
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2091.452
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Polar area
|
554.02
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Complexity
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.
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xlogp Value
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3.67212
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Heavy Count
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144
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Rot Bonds
|
98
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Hbond acc
|
37
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker