Linker Information
General Information of This Linker
| Linker ID |
LIN0ROUFT
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| Linker Name |
Linker of ADC2-27
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C31H47N7O14
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)CCC(NC(O2)[C@H](O)[C@H](O)[C@H]2C(O)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(O)=O)=O)C
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| InChI |
InChI=1S/C31H47N7O14/c1-15(2)22(27(46)35-17(29(47)48)7-6-13-33-31(32)51)37-26(45)16(9-10-19(40)36-28-24(44)23(43)25(52-28)30(49)50)34-18(39)8-4-3-5-14-38-20(41)11-12-21(38)42/h11-12,15-17,22-25,28,43-44H,3-10,13-14H2,1-2H3,(H,34,39)(H,35,46)(H,36,40)(H,37,45)(H,47,48)(H,49,50)(H3,32,33,51)/t16-,17-,22-,23-,24+,25-,28?/m0/s1
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| InChIKey |
KCHBWCSEDAWVHI-ASOLLSRVSA-N
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| Pharmaceutical Properties |
Molecule Weight
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741.752
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Polar area
|
333.19
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Complexity
|
1301.17477
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xlogp Value
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-3.457
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Heavy Count
|
52
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Rot Bonds
|
22
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Hbond acc
|
12
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Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker