Linker Information
General Information of This Linker
| Linker ID |
LIN0RNEVV
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| Linker Name |
Linker of ADC2-31
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C38H53N7O14S
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| Isosmiles |
O=C(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)=O)=O)[C@@H](NC(CCCCCN2C(C=CC2=O)=O)=O)CCCCNC(C[C@H](O3)[C@H](O)[C@H](O)[C@H]3CO)=O.[S]
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| InChI |
InChI=1S/C38H53N7O14.S/c46-22-27-36(56)35(55)26(59-27)18-29(48)39-15-7-6-11-24(43-28(47)12-5-2-8-16-45-32(51)13-14-33(45)52)37(57)41-19-30(49)40-20-31(50)44-25(38(58)42-21-34(53)54)17-23-9-3-1-4-10-23;/h1,3-4,9-10,13-14,24-27,35-36,46,55-56H,2,5-8,11-12,15-22H2,(H,39,48)(H,40,49)(H,41,57)(H,42,58)(H,43,47)(H,44,50)(H,53,54);/t24-,25-,26-,27+,35-,36+;/m0./s1
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| InChIKey |
FRKUWTMVEKOVQC-RYKYWMJESA-N
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| Pharmaceutical Properties |
Molecule Weight
|
863.944
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Polar area
|
319.2
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Complexity
|
1583.569829
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xlogp Value
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-3.0764
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Heavy Count
|
60
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Rot Bonds
|
26
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Hbond acc
|
13
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Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker