Linker Information
General Information of This Linker
| Linker ID |
LIN0RMVIS
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| Linker Name |
Gly5-FITC
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| Linker Type |
Sortase-based site-specific conjugation linker
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| Antibody-Linker Relation |
Uncleavable
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
HuXBR1-402-G5-PNU [Clinical candidate]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
1.27 ng/mL
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Positive ROR1 expression (ROR1+++/++) | ||
| Method Description |
Cell lines obtained from ATCC were serum starved for 16 hours and reintroduced to full serum media supplemented huXBR1-402-G5-PNU for 72 hours. Viability was measured by using MTS assays, and relative light unit (RLU) values for each dose were generated after 72 hours of treatment in 2 independent experiments.
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| In Vitro Model | Childhood B acute lymphoblastic leukemia | Kasumi-2 cells | CVCL_0590 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
75.68 ng/mL
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Positive ROR1 expression (ROR1+++/++) | ||
| Method Description |
Cell lines obtained from ATCC were serum starved for 16 hours and reintroduced to full serum media supplemented huXBR1-402-G5-PNU for 72 hours. Viability was measured by using MTS assays, and relative light unit (RLU) values for each dose were generated after 72 hours of treatment in 2 independent experiments.
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| In Vitro Model | Childhood B acute lymphoblastic leukemia | 697 cells | CVCL_0079 | ||
References
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