Linker Information
General Information of This Linker
| Linker ID |
LIN0RJDTE
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|---|---|---|---|---|---|---|
| Linker Name |
aHer2- (AL6-LP13D)<sub>6.2</sub> Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C77H109N15O24
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| Isosmiles |
O=C(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)CNC(CCOCCOCCNC(CN(CC(NCCOCCOCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(O)=O)=O)=O)=O)=O)=O)CCOCCOCCOCCNC(COC(CCCCC3)C4=C3C(C5=CC=C(CNC(C)=O)C=C5)=NN=C4)=O)=O)=O
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| InChI |
InChI=1S/C77H109N15O24/c1-54(93)81-43-57-17-19-58(20-18-57)75-59-15-9-4-10-16-63(60(59)44-88-91-75)116-53-72(102)80-25-31-113-37-39-115-40-38-114-32-26-92(51-70(100)78-23-29-111-35-33-109-27-21-64(94)82-45-66(96)84-47-68(98)89-61(76(107)86-49-73(103)104)41-55-11-5-2-6-12-55)52-71(101)79-24-30-112-36-34-110-28-22-65(95)83-46-67(97)85-48-69(99)90-62(77(108)87-50-74(105)106)42-56-13-7-3-8-14-56/h2-3,5-8,11-14,17-20,44,61-63H,4,9-10,15-16,21-43,45-53H2,1H3,(H,78,100)(H,79,101)(H,80,102)(H,81,93)(H,82,94)(H,83,95)(H,84,96)(H,85,97)(H,86,107)(H,87,108)(H,89,98)(H,90,99)(H,103,104)(H,105,106)/t61-,62-,63?/m0/s1
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| InChIKey |
QEYKMOGAHNCMHV-WIWXTBCNSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1628.8
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Polar area
|
526.66
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Complexity
|
3421.289475
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xlogp Value
|
-3.1777
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Heavy Count
|
116
|
Rot Bonds
|
60
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Hbond acc
|
25
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Hbond Donor
|
14
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Each Antibody-drug Conjugate Related to This Linker