General Information of This Linker
Linker ID
LIN0RGNUP
Linker Name
Anti-Her2-AL1- LP23 linker
Linker Type
Cathepsin-cleavable linker
Antibody-Linker Relation
Cleavable
Structure
Formula
C112H157FN22O33
Isosmiles
NCCOCCOCCOCCN(N=N1)C2=C1C(OCC(NCCOCCOCCOCCOCCC(N[C@H](CCCCN(N=N3)C4=C3C(OCC(NCCOCCOCCOCCOCCC(NCC(NCC(N[C@@H](CC5=CC=CC=C5)C(NCC(NCOCC(N[C@H]6CCC7=C8C6=C9CN(C(C9=NC8=CC(F)=C7C)=C%10)C(C(CO%11)=C%10[C@](C)(O)C%11=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCCC4)C(NCC(NCC(N[C@@H](CC%12=CC=CC=C%12)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)CCCCC2
InChI
InChI=1S/C112H157FN22O33/c1-73-76-26-27-81(103-77-67-133-88(104(77)128-83(102(76)103)60-80(73)113)59-79-78(110(133)151)68-168-111(152)112(79,2)153)124-100(145)69-165-72-123-95(140)63-121-108(149)84(57-74-17-7-3-8-18-74)126-96(141)64-118-93(138)61-117-91(136)28-35-154-41-47-160-53-55-163-50-44-157-38-31-115-98(143)70-166-89-24-13-5-11-22-86-105(89)129-131-134(86)33-16-15-21-82(107(148)120-62-94(139)119-65-97(142)127-85(109(150)122-66-101(146)147)58-75-19-9-4-10-20-75)125-92(137)29-36-155-42-48-161-54-56-164-51-45-158-39-32-116-99(144)71-167-90-25-14-6-12-23-87-106(90)130-132-135(87)34-40-159-46-52-162-49-43-156-37-30-114/h3-4,7-10,17-20,59-60,81-82,84-85,89-90,153H,5-6,11-16,21-58,61-72,114H2,1-2H3,(H,115,143)(H,116,144)(H,117,136)(H,118,138)(H,119,139)(H,120,148)(H,121,149)(H,122,150)(H,123,140)(H,124,145)(H,125,137)(H,126,141)(H,127,142)(H,146,147)/t81-,82+,84-,85-,89?,90?,112-/m0/s1
InChIKey
IYECRHQJUTXJLO-KIZSRHLMSA-N
Pharmaceutical Properties
Molecule Weight
2358.607
Polar area
713.68
Complexity
.
xlogp Value
-1.69158
Heavy Count
168
Rot Bonds
79
Hbond acc
41
Hbond Donor
16
Each Antibody-drug Conjugate Related to This Linker