Linker Information
General Information of This Linker
| Linker ID |
LIN0REOWV
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| Linker Name |
P5 (PEG24)-VA-PAB linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C73H127N4O32PS
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| Isosmiles |
CC([C@H](NC(C1=CC=C(NP(/C=C\S)(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)=O)C=C1)=O)C(N[C@@H](C)C(NC2=CC=C(COC(O)=O)C=C2)=O)=O)C
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| InChI |
InChI=1S/C73H127N4O32PS/c1-63(2)69(72(81)74-64(3)70(79)75-67-8-4-65(5-9-67)62-108-73(82)83)76-71(80)66-6-10-68(11-7-66)77-110(84,60-61-111)109-59-58-107-57-56-106-55-54-105-53-52-104-51-50-103-49-48-102-47-46-101-45-44-100-43-42-99-41-40-98-39-38-97-37-36-96-35-34-95-33-32-94-31-30-93-29-28-92-27-26-91-25-24-90-23-22-89-21-20-88-19-18-87-17-16-86-15-14-85-13-12-78/h4-11,60-61,63-64,69,78,111H,12-59,62H2,1-3H3,(H,74,81)(H,75,79)(H,76,80)(H,77,84)(H,82,83)/b61-60-/t64-,69-,110?/m0/s1
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| InChIKey |
GJJBZHRECMUHLX-DGWYIKQOSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1635.856
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Polar area
|
404.68
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Complexity
|
2415.6031
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xlogp Value
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4.1757
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Heavy Count
|
111
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Rot Bonds
|
84
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Hbond acc
|
32
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker