Linker Information
General Information of This Linker
| Linker ID |
LIN0RDSDE
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| Linker Name |
CN117731799A-ADC-1-linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C42H55N11O9
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| Isosmiles |
O=C(N1CC(N=N2)C=CN2CC(NC3CCC(C3)C(NCNCC(ONC(C4=CC=CC=C4)C(CNC(NC5=CC=C(CCC(O)=O)C=C5)CCCCN)=O)=O)=O)=O)C=CC1=O
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| InChI |
InChI=1S/C42H55N11O9/c43-20-5-4-8-35(47-31-13-9-28(10-14-31)11-18-39(58)59)45-23-34(54)41(29-6-2-1-3-7-29)50-62-40(60)24-44-27-46-42(61)30-12-15-32(22-30)48-36(55)26-52-21-19-33(49-51-52)25-53-37(56)16-17-38(53)57/h1-3,6-7,9-10,13-14,16-17,19,21,30,32-33,35,41,44-45,47,50H,4-5,8,11-12,15,18,20,22-27,43H2,(H,46,61)(H,48,55)(H,58,59)
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| InChIKey |
KIVJICFKRGPTMF-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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857.97
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Polar area
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278.35
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Complexity
|
1853.644877
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xlogp Value
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0.9569
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Heavy Count
|
62
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Rot Bonds
|
26
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Hbond acc
|
16
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker