Linker Information
General Information of This Linker
| Linker ID |
LIN0RCKEB
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| Linker Name |
JP2024533562A ADC-16 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C27H38N6O9
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| Isosmiles |
CC([C@H](NC(OCCOCCN1C(C=CC1=O)=O)=O)C(NC(CCCNC(N)=O)C(NC2=CC=C(CO)C=C2)=O)=O)C
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| InChI |
InChI=1S/C27H38N6O9/c1-17(2)23(32-27(40)42-15-14-41-13-12-33-21(35)9-10-22(33)36)25(38)31-20(4-3-11-29-26(28)39)24(37)30-19-7-5-18(16-34)6-8-19/h5-10,17,20,23,34H,3-4,11-16H2,1-2H3,(H,30,37)(H,31,38)(H,32,40)(H3,28,29,39)/t20?,23-/m0/s1
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| InChIKey |
HTNGHIKQRXTBSP-AKRCKQFNSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
590.634
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Polar area
|
218.49
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Complexity
|
1067.352422
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xlogp Value
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-0.2569
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Heavy Count
|
42
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Rot Bonds
|
17
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Hbond acc
|
9
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Hbond Donor
|
6
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Each Antibody-drug Conjugate Related to This Linker