Linker Information
General Information of This Linker
| Linker ID |
LIN0RAUJA
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|---|---|---|---|---|---|---|
| Linker Name |
Mal-Val-Cit-glucuronide-PABC
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C30H39N3O12
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| Isosmiles |
CC(NC(=O)C(CC(=O)CN1C(=O)C=CC1=O)C(C)C)C(=O)Nc1ccc(CO)c(CCC2OC(C(=O)O)C(O)C(O)C2O)c1
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| InChI |
InChI=1S/C30H39N3O12/c1-14(2)20(11-19(35)12-33-22(36)8-9-23(33)37)29(42)31-15(3)28(41)32-18-6-4-17(13-34)16(10-18)5-7-21-24(38)25(39)26(40)27(45-21)30(43)44/h4,6,8-10,14-15,20-21,24-27,34,38-40H,5,7,11-13H2,1-3H3,(H,31,42)(H,32,41)(H,43,44)
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| InChIKey |
NESNDEVGUGPURM-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
633.651
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Polar area
|
240.1
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Complexity
|
45
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xlogp Value
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-1.3542
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Heavy Count
|
45
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Rot Bonds
|
14
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Hbond acc
|
11
|
Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker
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