Linker Information
General Information of This Linker
| Linker ID |
LIN0QZPJV
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| Linker Name |
WO2024020536A1+HER-E-44+Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C27H36N6O8
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| Isosmiles |
CN(CCNC([C@@H](NC(CNC(CNC(CCCCCN1C(C=CC1=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)C(O)=O
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| InChI |
InChI=1S/C27H36N6O8/c1-32(27(40)41)15-13-28-26(39)20(16-19-8-4-2-5-9-19)31-23(36)18-30-22(35)17-29-21(34)10-6-3-7-14-33-24(37)11-12-25(33)38/h2,4-5,8-9,11-12,20H,3,6-7,10,13-18H2,1H3,(H,28,39)(H,29,34)(H,30,35)(H,31,36)(H,40,41)/t20-/m0/s1
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| InChIKey |
FSJNVNXWQYPAEI-FQEVSTJZSA-N
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| Pharmaceutical Properties |
Molecule Weight
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572.619
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Polar area
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194.32
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Complexity
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1070.10731
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xlogp Value
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-0.8423
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Heavy Count
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41
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Rot Bonds
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17
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Hbond acc
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7
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
HER-E-44 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
. pM
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High HER2 expression (HER2 +++) | ||
| Method Description |
A Cell line test on SKBR-3
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||