Linker Information
General Information of This Linker
| Linker ID |
LIN0QTUMB
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
IG-L-26 linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C61H84N14O21
|
|||||
| Isosmiles |
C[C@H](NC([C@H](C)NC(CCC1=CC=C(N2C(C=CC2=O)=O)C=C1OCCCC(N(C)CC(N(CC(N(C)CC(N(CC(N(C)CC(N(CC(N(C)CC(N(CC(N(C)CC(N(CC(O)=O)C)=O)=O)C)=O)=O)C)=O)=O)C)=O)=O)C)=O)=O)=O)=O)C(NC3=CC=C(C=C3)COC(O)=O)=O
|
|||||
| InChI |
InChI=1S/C61H84N14O21/c1-38(59(91)63-39(2)60(92)64-42-19-15-40(16-20-42)37-96-61(93)94)62-45(76)22-18-41-17-21-43(75-47(78)23-24-48(75)79)26-44(41)95-25-13-14-46(77)65(3)27-49(80)66(4)28-50(81)67(5)29-51(82)68(6)30-52(83)69(7)31-53(84)70(8)32-54(85)71(9)33-55(86)72(10)34-56(87)73(11)35-57(88)74(12)36-58(89)90/h15-17,19-21,23-24,26,38-39H,13-14,18,22,25,27-37H2,1-12H3,(H,62,76)(H,63,91)(H,64,92)(H,89,90)(H,93,94)/t38-,39-/m0/s1
|
|||||
| InChIKey |
ITAGNTXFBMNCHA-YDAXCOIMSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
1349.42
|
Polar area
|
420.84
|
||
|
Complexity
|
3162.920651
|
xlogp Value
|
-3.2811
|
|||
|
Heavy Count
|
96
|
Rot Bonds
|
36
|
|||
|
Hbond acc
|
19
|
Hbond Donor
|
5
|
|||
Each Antibody-drug Conjugate Related to This Linker