Linker Information
General Information of This Linker
| Linker ID |
LIN0QQCIX
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| Linker Name |
Phenoxy silyl linker 37
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| Linker Type |
Reduction sensitive linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C38H58N6O13S2Si
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| Isosmiles |
CC([Si](OC1=CC=C(CO)C=C1OC)(OCCOCC(N=N2)=CN2CCOCCOCCOCCNC(C3=CC(NS(C=C)(=O)=O)=CC(NS(C=C)(=O)=O)=C3)=O)C(C)C)C
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| InChI |
InChI=1S/C38H58N6O13S2Si/c1-8-58(47,48)41-33-23-32(24-34(25-33)42-59(49,50)9-2)38(46)39-12-14-52-16-18-54-19-17-53-15-13-44-26-35(40-43-44)28-55-20-21-56-60(29(3)4,30(5)6)57-36-11-10-31(27-45)22-37(36)51-7/h8-11,22-26,29-30,41-42,45H,1-2,12-21,27-28H2,3-7H3,(H,39,46)
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| InChIKey |
MLLZNPNQAYACGH-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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899.131
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Polar area
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236.99
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Complexity
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1893.690216
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xlogp Value
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3.9036
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Heavy Count
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60
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Rot Bonds
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31
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Hbond acc
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16
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
39914224 Ate-37 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
4.27 nM
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Positive PD-L1 expression (PD-L1+++/++) | ||
| Method Description |
The starting point of the small molecule drug was 500 nM, and the drug was diluted 5 times sequentially, for a total of eight concentration points. Cells were laid on 96-well plate at 4000 cells/well, cultured overnight and were added with diluted drugs, in the incubator for 72 h. All cells incubated with the drug were tested for cell viability using Cell Counting Kit-8 (CCK-8) kit (Meilunbio, Dalian, China).
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| In Vitro Model | Glioblastoma | U87 cells | CVCL_0022 | ||
References