Linker Information
General Information of This Linker
| Linker ID |
LIN0QOKHV
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| Linker Name |
Linker of ADC2-44
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C36H49N9O16
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| Isosmiles |
O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)=O)[C@@H](NC(CCNC(CNC(/C=C\C(O)=O)=O)=O)=O)CCC(NC[C@@H]2[C@@H](O)[C@@H](O)[C@H](CC(N)=O)O2)=O
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| InChI |
InChI=1S/C36H49N9O16/c37-24(46)13-22-33(57)34(58)23(61-22)14-39-25(47)7-6-20(44-27(49)10-11-38-28(50)15-40-26(48)8-9-31(53)54)35(59)42-16-29(51)41-17-30(52)45-21(36(60)43-18-32(55)56)12-19-4-2-1-3-5-19/h1-5,8-9,20-23,33-34,57-58H,6-7,10-18H2,(H2,37,46)(H,38,50)(H,39,47)(H,40,48)(H,41,51)(H,42,59)(H,43,60)(H,44,49)(H,45,52)(H,53,54)(H,55,56)/b9-8-/t20-,21-,22-,23+,33-,34+/m0/s1
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| InChIKey |
XORZYXWHZGAXSM-ODYQARNDSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
863.835
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Polar area
|
400.18
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Complexity
|
1711.164317
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xlogp Value
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-6.8438
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Heavy Count
|
61
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Rot Bonds
|
26
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Hbond acc
|
14
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Hbond Donor
|
13
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Each Antibody-drug Conjugate Related to This Linker