Linker Information
General Information of This Linker
| Linker ID |
LIN0QFSQA
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| Linker Name |
RKAA-PABC
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C26H43N9O7
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| Isosmiles |
OCC1=CC=C(NC([C@H](C)NC([C@@H](NC([C@@H](NC([C@@H](NC(O)=O)CCCNC(N)=N)=O)CCCCN)=O)C)=O)=O)C=C1
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| InChI |
InChI=1S/C26H43N9O7/c1-15(21(37)31-16(2)22(38)33-18-10-8-17(14-36)9-11-18)32-23(39)19(6-3-4-12-27)34-24(40)20(35-26(41)42)7-5-13-30-25(28)29/h8-11,15-16,19-20,35-36H,3-7,12-14,27H2,1-2H3,(H,31,37)(H,32,39)(H,33,38)(H,34,40)(H,41,42)(H4,28,29,30)/t15-,16-,19-,20-/m0/s1
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| InChIKey |
KPRCDQXHXYWIGK-FVCZOJIISA-N
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| Pharmaceutical Properties |
Molecule Weight
|
593.686
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Polar area
|
273.88
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Complexity
|
1012.622967
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xlogp Value
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-1.35993
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Heavy Count
|
42
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Rot Bonds
|
18
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Hbond acc
|
8
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Hbond Donor
|
11
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Each Antibody-drug Conjugate Related to This Linker