Linker Information
General Information of This Linker
| Linker ID |
LIN0QEQKG
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| Linker Name |
IG-L-21 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C56H79N9O21
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| Isosmiles |
C[C@H](NC(CCC1=CC=C(N2C(C=CC2=O)=O)C=C1OCCCC(N(C)CCOCC(N(C)CCOCC(N(C)CCOCC(N(C)CCOCC(N(C)CCOCC(O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](C)C(NC3=CC=C(C=C3)COC(O)=O)=O)=O
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| InChI |
InChI=1S/C56H79N9O21/c1-38(54(76)58-39(2)55(77)59-42-14-10-40(11-15-42)32-86-56(78)79)57-45(66)17-13-41-12-16-43(65-47(68)18-19-48(65)69)31-44(41)85-25-8-9-46(67)60(3)20-26-80-33-49(70)61(4)21-27-81-34-50(71)62(5)22-28-82-35-51(72)63(6)23-29-83-36-52(73)64(7)24-30-84-37-53(74)75/h10-12,14-16,18-19,31,38-39H,8-9,13,17,20-30,32-37H2,1-7H3,(H,57,66)(H,58,76)(H,59,77)(H,74,75)(H,78,79)/t38-,39-/m0/s1
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| InChIKey |
HNWYWFKODFJLMQ-YDAXCOIMSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1214.29
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Polar area
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365.44
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Complexity
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2549.03681
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xlogp Value
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-0.4901
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Heavy Count
|
86
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Rot Bonds
|
41
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Hbond acc
|
19
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker