Linker Information
General Information of This Linker
| Linker ID |
LIN0QELJC
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| Linker Name |
EP4487874A1-20linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C58H94N13O21P
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| Isosmiles |
CN([C@@H](CCCCN(C)C)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(NC1=CC=C(CO)C=C1)=O)CCCNC(N)=O)=O)=O)CC(N[C@H]2CCOC2=O)=O)=O)CCNC(CCOCCOCCOCCOCCNC([C@@H](N3C(C=CC3=O)=O)CNC(CCP(O)(O)=O)=O)=O)=O
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| InChI |
InChI=1S/C58H94N13O21P/c1-38(2)51(56(82)66-41(9-8-20-62-58(59)84)52(78)64-40-13-11-39(37-72)12-14-40)68-53(79)43(35-48(75)65-42-17-26-92-57(42)83)67-55(81)44(10-6-7-23-69(3)4)70(5)24-21-60-46(73)18-25-88-28-30-90-32-33-91-31-29-89-27-22-61-54(80)45(71-49(76)15-16-50(71)77)36-63-47(74)19-34-93(85,86)87/h11-16,38,41-45,51,72H,6-10,17-37H2,1-5H3,(H,60,73)(H,61,80)(H,63,74)(H,64,78)(H,65,75)(H,66,82)(H,67,81)(H,68,79)(H3,59,62,84)(H2,85,86,87)/t41-,42-,43-,44-,45-,51-/m0/s1
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| InChIKey |
XOQUNPCMZKBHEV-RVLONWIRSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1340.434
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Polar area
|
472.76
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Complexity
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2555.373369
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xlogp Value
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-3.8031
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Heavy Count
|
93
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Rot Bonds
|
48
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Hbond acc
|
21
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Hbond Donor
|
13
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Each Antibody-drug Conjugate Related to This Linker