Linker Information
General Information of This Linker
| Linker ID |
LIN0QDAWM
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| Linker Name |
CN110997010A ADC-6 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C51H68N8O20S2
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| Isosmiles |
C[C@H](NC([C@@H](NC(OCCOCCN1C(C=CC1=O)=O)=O)C(C)C)=O)C(NC2=CC=C(COC(NC(CSC(CC3=O)C(N3CCCCCC(O)=O)=O)C(NC(C(O)=O)CSC(C4=O)CC(N4CCCCCC(O)=O)=O)=O)=O)C=C2)=O
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| InChI |
InChI=1S/C51H68N8O20S2/c1-29(2)43(56-51(76)78-23-22-77-21-20-57-37(60)16-17-38(57)61)46(70)52-30(3)44(68)53-32-14-12-31(13-15-32)26-79-50(75)55-33(27-80-35-24-39(62)58(47(35)71)18-8-4-6-10-41(64)65)45(69)54-34(49(73)74)28-81-36-25-40(63)59(48(36)72)19-9-5-7-11-42(66)67/h12-17,29-30,33-36,43H,4-11,18-28H2,1-3H3,(H,52,70)(H,53,68)(H,54,69)(H,55,75)(H,56,76)(H,64,65)(H,66,67)(H,73,74)/t30-,33?,34?,35?,36?,43-/m0/s1
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| InChIKey |
KSJCBZUDSRORPR-ZZSXCDOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1177.275
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Polar area
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397.23
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Complexity
|
2401.397478
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xlogp Value
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0.9978
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Heavy Count
|
81
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Rot Bonds
|
36
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Hbond acc
|
19
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Hbond Donor
|
8
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Each Antibody-drug Conjugate Related to This Linker