Linker Information
General Information of This Linker
| Linker ID |
LIN0PZJGZ
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| Linker Name |
CN119630431A-ADC-37-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C30H33N3O10S2
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| Isosmiles |
C[C@H](NC(CCOCCOCCN1C(C(SC2=CC=CC=C2)=C(SC3=CC=CC=C3)C1=O)=O)=O)C(N[C@H](C(O)=O)CC(O)=O)=O
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| InChI |
InChI=1S/C30H33N3O10S2/c1-19(27(37)32-22(30(40)41)18-24(35)36)31-23(34)12-14-42-16-17-43-15-13-33-28(38)25(44-20-8-4-2-5-9-20)26(29(33)39)45-21-10-6-3-7-11-21/h2-11,19,22H,12-18H2,1H3,(H,31,34)(H,32,37)(H,35,36)(H,40,41)/t19-,22-/m0/s1
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| InChIKey |
FUKDIOJHWFERDN-UGKGYDQZSA-N
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| Pharmaceutical Properties |
Molecule Weight
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659.739
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Polar area
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188.64
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Complexity
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1281.763068
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xlogp Value
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2.1235
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Heavy Count
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45
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Rot Bonds
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19
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Hbond acc
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10
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2024043319A1 26 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.032 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||