Linker Information
General Information of This Linker
| Linker ID |
LIN0PWYTE
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| Linker Name |
WO2023173026A1-ADC-L081-038-Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C26H45N5O8
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| Isosmiles |
CN(C)CCCC[C@H](NC(C1=CC=C(N)C(N)=C1)=O)C(NCCOCCOCCOCCOCCC(O)=O)=O
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| InChI |
InChI=1S/C26H45N5O8/c1-31(2)10-4-3-5-23(30-25(34)20-6-7-21(27)22(28)19-20)26(35)29-9-12-37-14-16-39-18-17-38-15-13-36-11-8-24(32)33/h6-7,19,23H,3-5,8-18,27-28H2,1-2H3,(H,29,35)(H,30,34)(H,32,33)/t23-/m0/s1
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| InChIKey |
YCHBTVKCOKQWJT-QHCPKHFHSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
555.673
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Polar area
|
187.7
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Complexity
|
807.327258
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xlogp Value
|
0.3386
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Heavy Count
|
39
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Rot Bonds
|
23
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Hbond acc
|
10
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker