Linker Information
General Information of This Linker
| Linker ID |
LIN0PTDRJ
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| Linker Name |
CN113874046B-ADC-5-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C50H72N12O10
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| Isosmiles |
CC([C@H](NC(C1=C(O)C=C(NC(CCOCCOCCNC2CCN(CC2)C(CCN3C4=C(C=C3CN(NC)C)C=CC=N4)=O)=O)C=C1)=O)C(N[C@@H](CCCNC(N)=O)C(NC5=CC=C(CO)C=C5)=O)=O)C
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| InChI |
InChI=1S/C50H72N12O10/c1-33(2)45(49(69)58-41(8-6-20-55-50(51)70)48(68)57-37-11-9-34(32-63)10-12-37)59-47(67)40-14-13-38(30-42(40)64)56-43(65)18-25-71-27-28-72-26-21-53-36-15-22-61(23-16-36)44(66)17-24-62-39(31-60(4)52-3)29-35-7-5-19-54-46(35)62/h5,7,9-14,19,29-30,33,36,41,45,52-53,63-64H,6,8,15-18,20-28,31-32H2,1-4H3,(H,56,65)(H,57,68)(H,58,69)(H,59,67)(H3,51,55,70)/t41-,45-/m0/s1
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| InChIKey |
LLFJOSOOPSTSMG-XMUJVIFGSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1001.2
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Polar area
|
295.87
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Complexity
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2322.029097
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xlogp Value
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2.1595
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Heavy Count
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72
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Rot Bonds
|
29
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Hbond acc
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15
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Hbond Donor
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10
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Each Antibody-drug Conjugate Related to This Linker