Linker Information
General Information of This Linker
| Linker ID |
LIN0PSYEN
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| Linker Name |
CN119630431A-ADC-26-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C37H39N5O8S2
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| Isosmiles |
O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)=O)CCCCCN2C(C(SC3=CC=CC=C3)=C(SC4=CC=CC=C4)C2=O)=O
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| InChI |
InChI=1S/C37H39N5O8S2/c43-29(38-22-30(44)39-23-31(45)41-28(35(48)40-24-32(46)47)21-25-13-5-1-6-14-25)19-11-4-12-20-42-36(49)33(51-26-15-7-2-8-16-26)34(37(42)50)52-27-17-9-3-10-18-27/h1-3,5-10,13-18,28H,4,11-12,19-24H2,(H,38,43)(H,39,44)(H,40,48)(H,41,45)(H,46,47)/t28-/m0/s1
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| InChIKey |
VMJVADHTBWRQTB-NDEPHWFRSA-N
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| Pharmaceutical Properties |
Molecule Weight
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745.88
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Polar area
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191.08
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Complexity
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1644.703734
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xlogp Value
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2.8725
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Heavy Count
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52
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Rot Bonds
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20
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Hbond acc
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9
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2024043319A1 15 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.039 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||