Linker Information
General Information of This Linker
| Linker ID |
LIN0PSLXL
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| Linker Name |
Anti-Her2-LP31 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C94H152N22O34
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| Isosmiles |
NCCOCCOCCOCCN(N=N1)C2=C1CC(NCCOCCOCCOCCN(CC(NCCOCCOCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)COC(NCC(O)=O)=O)=O)=O)C(C)C)=O)=O)=O)CC(NCCOCCOCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)COC(NCC(O)=O)=O)=O)=O)C(C)C)=O)=O)=O)CCCC2
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| InChI |
InChI=1S/C94H152N22O34/c1-62(2)83(89(133)109-69(10-7-28-101-91(96)135)85(129)105-66-17-13-64(14-18-66)60-149-93(137)103-56-81(125)126)111-87(131)71(21-23-79(121)122)107-75(117)25-35-139-43-46-143-39-31-99-77(119)58-115(33-41-145-49-53-148-52-48-142-38-30-98-68-9-5-6-12-74-73(55-68)113-114-116(74)34-42-146-50-54-147-51-45-141-37-27-95)59-78(120)100-32-40-144-47-44-140-36-26-76(118)108-72(22-24-80(123)124)88(132)112-84(63(3)4)90(134)110-70(11-8-29-102-92(97)136)86(130)106-67-19-15-65(16-20-67)61-150-94(138)104-57-82(127)128/h13-20,62-63,68-72,83-84,98H,5-12,21-61,95H2,1-4H3,(H,99,119)(H,100,120)(H,103,137)(H,104,138)(H,105,129)(H,106,130)(H,107,117)(H,108,118)(H,109,133)(H,110,134)(H,111,131)(H,112,132)(H,121,122)(H,123,124)(H,125,126)(H,127,128)(H3,96,101,135)(H3,97,102,136)/t68?,69-,70-,71-,72-,83-,84-/m0/s1
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| InChIKey |
DCFMHXJDDBTXAD-UDXVGBPOSA-N
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| Pharmaceutical Properties |
Molecule Weight
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2134.37
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Polar area
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791.4
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Complexity
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.
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xlogp Value
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-3.3091
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Heavy Count
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150
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Rot Bonds
|
84
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Hbond acc
|
36
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Hbond Donor
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22
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Each Antibody-drug Conjugate Related to This Linker