Linker Information
General Information of This Linker
| Linker ID |
LIN0PRHDV
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| Linker Name |
DM-II Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C57H77N13O15
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| Isosmiles |
CN(C(C(N[C@H](C)C1=O)=O)=C)C(CC[C@H](C(O)=O)NC([C@@H](C)C(NC([C@H](CCCNC(N)=N)NC([C@@H](C)[C@H](C(O)=O)NC([C@H](CC2=CC=C(OCC(N=N3)=CN3CC(O)=O)C=C2)N1)=O)=O)=O)/C=C/C(C)=C/[C@H](C)C(OC)CC4=CC=CC=C4)=O)=O
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| InChI |
InChI=1S/C57H77N13O15/c1-31(25-32(2)45(84-8)27-37-13-10-9-11-14-37)16-21-41-33(3)49(74)64-43(55(80)81)22-23-46(71)69(7)36(6)52(77)61-35(5)51(76)65-44(26-38-17-19-40(20-18-38)85-30-39-28-70(68-67-39)29-47(72)73)54(79)66-48(56(82)83)34(4)50(75)63-42(53(78)62-41)15-12-24-60-57(58)59/h9-11,13-14,16-21,25,28,32-35,41-45,48H,6,12,15,22-24,26-27,29-30H2,1-5,7-8H3,(H,61,77)(H,62,78)(H,63,75)(H,64,74)(H,65,76)(H,66,79)(H,72,73)(H,80,81)(H,82,83)(H4,58,59,60)/b21-16+,31-25+/t32-,33-,34-,35+,41?,42-,43+,44-,45?,48+/m0/s1
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| InChIKey |
MRRBZXQLVVFSSV-RLSYYCQISA-N
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| Pharmaceutical Properties |
Molecule Weight
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1184.319
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Polar area
|
417.88
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Complexity
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2844.171036
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xlogp Value
|
0.27977
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Heavy Count
|
85
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Rot Bonds
|
20
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Hbond acc
|
16
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Hbond Donor
|
12
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Each Antibody-drug Conjugate Related to This Linker