Linker Information
General Information of This Linker
| Linker ID |
LIN0PQLVY
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| Linker Name |
Aminobenzazepine-linker Formula II-15
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C30H37F4N5O8
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| Isosmiles |
CC(C)[C@H](NC(CCOCCC(OC1=C(F)C(F)=CC(F)=C1F)=O)=O)C(N[C@H](C(NC2=CC=C(CO)C=C2)=O)CCCNC(N)=O)=O
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| InChI |
InChI=1S/C30H37F4N5O8/c1-16(2)26(39-22(41)9-12-46-13-10-23(42)47-27-24(33)19(31)14-20(32)25(27)34)29(44)38-21(4-3-11-36-30(35)45)28(43)37-18-7-5-17(15-40)6-8-18/h5-8,14,16,21,26,40H,3-4,9-13,15H2,1-2H3,(H,37,43)(H,38,44)(H,39,41)(H3,35,36,45)/t21-,26-/m0/s1
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| InChIKey |
FBHXKNHGBDQJID-LVXARBLLSA-N
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| Pharmaceutical Properties |
Molecule Weight
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671.645
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Polar area
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198.18
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Complexity
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1315.14741
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xlogp Value
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2.1503
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Heavy Count
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47
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Rot Bonds
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18
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Hbond acc
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8
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2020291014A1 IC-9 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
161.03 nM
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| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||
AU2020291014A1 IC-8 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
233.7 nM
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| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||