Linker Information
General Information of This Linker
| Linker ID |
LIN0PLADS
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| Linker Name |
CN110997010A ADC-7 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C76H117N9O31S2
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| Isosmiles |
C[C@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)C(C)C)=O)C(NC2=CC=C(COC(NC(CSC(CC3=O)C(N3CCCCCC(O)=O)=O)C(NC(C(O)=O)CSC(C4=O)CC(N4CCCCCC(O)=O)=O)=O)=O)C=C2)=O
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| InChI |
InChI=1S/C76H117N9O31S2/c1-53(2)69(82-62(87)19-24-104-26-28-106-30-32-108-34-36-110-38-40-112-42-44-114-46-47-115-45-43-113-41-39-111-37-35-109-33-31-107-29-27-105-25-20-77-61(86)18-23-83-63(88)16-17-64(83)89)72(98)78-54(3)70(96)79-56-14-12-55(13-15-56)50-116-76(103)81-57(51-117-59-48-65(90)84(73(59)99)21-8-4-6-10-67(92)93)71(97)80-58(75(101)102)52-118-60-49-66(91)85(74(60)100)22-9-5-7-11-68(94)95/h12-17,53-54,57-60,69H,4-11,18-52H2,1-3H3,(H,77,86)(H,78,98)(H,79,96)(H,80,97)(H,81,103)(H,82,87)(H,92,93)(H,94,95)(H,101,102)/t54-,57?,58?,59?,60?,69-/m0/s1
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| InChIKey |
FYUMTUQSMHDVCN-WVILDMSOSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1716.938
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Polar area
|
518.63
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Complexity
|
3136.35246
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xlogp Value
|
0.4668
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Heavy Count
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118
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Rot Bonds
|
72
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Hbond acc
|
30
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Hbond Donor
|
9
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Each Antibody-drug Conjugate Related to This Linker