Linker Information
General Information of This Linker
| Linker ID |
LIN0PKWZQ
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|---|---|---|---|---|---|---|
| Linker Name |
WO2024105205A1-4c-1015-Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C20H29N5O8
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| Isosmiles |
O=C(O)[C@@H](NC([C@@H](C)NC([C@H](C)NC(CCCCCN1C(C=CC1=O)=O)=O)=O)=O)CC(N)=O
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| InChI |
InChI=1S/C20H29N5O8/c1-11(18(30)23-12(2)19(31)24-13(20(32)33)10-14(21)26)22-15(27)6-4-3-5-9-25-16(28)7-8-17(25)29/h7-8,11-13H,3-6,9-10H2,1-2H3,(H2,21,26)(H,22,27)(H,23,30)(H,24,31)(H,32,33)/t11-,12+,13-/m0/s1
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| InChIKey |
OXBRKUZUVYEFFY-XQQFMLRXSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
467.479
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Polar area
|
205.07
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Complexity
|
777.8949464
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xlogp Value
|
-2.074
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Heavy Count
|
33
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Rot Bonds
|
14
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Hbond acc
|
7
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker