Linker Information
General Information of This Linker
| Linker ID |
LIN0PJGNJ
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| Linker Name |
MC-Val-Ala-RG-14
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C44H60N8O11
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| Isosmiles |
O=C(N[C@@H](C)C(NC1=CC=C(COC(NCC2=CC=CC=C2N(CCN3CCN(CCCC(O)=O)CC3)C(O)=O)=O)C=C1)=O)[C@H](C(C)C)NC(CCCCCN4C(C=CC4=O)=O)=O
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| InChI |
InChI=1S/C44H60N8O11/c1-30(2)40(48-36(53)12-5-4-8-21-52-37(54)18-19-38(52)55)42(59)46-31(3)41(58)47-34-16-14-32(15-17-34)29-63-43(60)45-28-33-10-6-7-11-35(33)51(44(61)62)27-26-50-24-22-49(23-25-50)20-9-13-39(56)57/h6-7,10-11,14-19,30-31,40H,4-5,8-9,12-13,20-29H2,1-3H3,(H,45,60)(H,46,59)(H,47,58)(H,48,53)(H,56,57)(H,61,62)/t31-,40-/m0/s1
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| InChIKey |
YMADZJVYZCSHFS-UDAPDHLFSA-N
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| Pharmaceutical Properties |
Molecule Weight
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877.009
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Polar area
|
247.33
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Complexity
|
1857.016724
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xlogp Value
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3.1492
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Heavy Count
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63
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Rot Bonds
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24
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Hbond acc
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11
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Hbond Donor
|
6
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Each Antibody-drug Conjugate Related to This Linker