Linker Information
General Information of This Linker
| Linker ID |
LIN0PHMXW
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|---|---|---|---|---|---|---|
| Linker Name |
T-3-AB Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C51H64N6O24S
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| Isosmiles |
OC1=CC=C(OS(=O)(OC2=C(O[C@@H]3[C@@H](O)[C@@H](O)[C@@H](O)[C@@H](C=O)O3)C=CC(C(NCCOCCOCCOCCN4C=C(COCCOCCOCCOCCNC(C5=CC(C(/C=C/C(N)=O)=O)=CC(C(OC)=O)=C5)=O)N=N4)=O)=C2)=O)C=C1
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| InChI |
InChI=1S/C51H64N6O24S/c1-70-50(67)36-27-34(40(60)7-9-44(52)61)26-35(28-36)49(66)54-11-14-72-17-20-75-22-23-76-24-25-77-32-37-30-57(56-55-37)12-15-73-18-21-74-19-16-71-13-10-53-48(65)33-2-8-41(78-51-47(64)46(63)45(62)43(31-58)79-51)42(29-33)81-82(68,69)80-39-5-3-38(59)4-6-39/h2-9,26-31,43,45-47,51,59,62-64H,10-25,32H2,1H3,(H2,52,61)(H,53,65)(H,54,66)/b9-7+/t43-,45+,46+,47+,51+/m1/s1
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| InChIKey |
KEIJZLVFAZEGPL-ZTYODYHUSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1177.158
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Polar area
|
409.03
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Complexity
|
2730.144617
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xlogp Value
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-1.4414
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Heavy Count
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82
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Rot Bonds
|
39
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Hbond acc
|
27
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Hbond Donor
|
7
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Each Antibody-drug Conjugate Related to This Linker