Linker Information
General Information of This Linker
| Linker ID |
LIN0PDINH
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| Linker Name |
Aminobenzazepine-linker Formula II-27
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C62H112F4N2O28
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| Isosmiles |
FC1=C(OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCCN)=O)=O)C(F)=C(F)C=C1F
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| InChI |
InChI=1S/C62H112F4N2O28/c63-56-55-57(64)61(66)62(60(56)65)96-59(70)2-6-72-8-10-74-12-14-76-16-18-78-20-22-80-24-26-82-28-30-84-32-34-86-36-38-88-40-42-90-44-46-92-48-50-94-52-54-95-53-51-93-49-47-91-45-43-89-41-39-87-37-35-85-33-31-83-29-27-81-25-23-79-21-19-77-17-15-75-13-11-73-9-7-71-5-1-58(69)68-4-3-67/h55H,1-54,67H2,(H,68,69)
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| InChIKey |
DBTMBYAGYPDUCJ-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1409.556
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Polar area
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312.17
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Complexity
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1664.808376
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xlogp Value
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1.4185
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Heavy Count
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96
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Rot Bonds
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81
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Hbond acc
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29
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Hbond Donor
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2
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2020291014A1 IC-19 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||