Linker Information
General Information of This Linker
| Linker ID |
LIN0PCSYV
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|---|---|---|---|---|---|---|
| Linker Name |
Dasatinib disulfide cleavable linker
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| Linker Type |
Thiol-sensitive linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C39H53N11O21S2
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| Isosmiles |
N=C(N)NCCCC(NC(=O)C(CC(=O)O)NC(=O)CCC(NC(=O)CO/N=C/c1ccc(C(N)=O)cc1)C(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CSSCCOC(=O)O)C(=O)O
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| InChI |
InChI=1S/C39H53N11O21S2/c40-31(59)19-5-3-18(4-6-19)15-44-71-16-27(52)45-21(36(64)65)7-8-26(51)46-22(12-28(53)54)33(61)47-20(2-1-9-43-38(41)42)32(60)48-23(13-29(55)56)34(62)49-24(14-30(57)58)35(63)50-25(37(66)67)17-73-72-11-10-70-39(68)69/h3-6,15,20-25H,1-2,7-14,16-17H2,(H2,40,59)(H,45,52)(H,46,51)(H,47,61)(H,48,60)(H,49,62)(H,50,63)(H,53,54)(H,55,56)(H,57,58)(H,64,65)(H,66,67)(H,68,69)(H4,41,42,43)/b44-15+
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| InChIKey |
SRKJGLOMPNSMKQ-AMZBJARSSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1076.043
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Polar area
|
534.21
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Complexity
|
73
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xlogp Value
|
-4.24243
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Heavy Count
|
73
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Rot Bonds
|
36
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Hbond acc
|
19
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Hbond Donor
|
16
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Each Antibody-drug Conjugate Related to This Linker
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