Linker Information
General Information of This Linker
| Linker ID |
LIN0PBVLM
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|---|---|---|---|---|---|---|
| Linker Name |
BCN-linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C58H84N10O25S2
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| Isosmiles |
CC([C@H](NC(OCCN(S(=O)(NC(OCCOCCNS(=O)(NC(OC[C@@H]1[C@]2([H])CCC#CCC[C@@]21[H])=O)=O)=O)=O)CCOC(N[C@H](C(N[C@@H](C)C(NC3=CC=C(C=C3)COCOCC(O)=O)=O)=O)C(C)C)=O)=O)C(N[C@@H](C)C(NC4=CC=C(C=C4)COCOCC(O)=O)=O)=O)C
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| InChI |
InChI=1S/C58H84N10O25S2/c1-36(2)49(53(75)60-38(5)51(73)62-42-17-13-40(14-18-42)29-86-34-88-32-47(69)70)64-55(77)90-25-22-68(95(83,84)67-58(80)92-28-27-85-24-21-59-94(81,82)66-57(79)93-31-46-44-11-9-7-8-10-12-45(44)46)23-26-91-56(78)65-50(37(3)4)54(76)61-39(6)52(74)63-43-19-15-41(16-20-43)30-87-35-89-33-48(71)72/h13-20,36-39,44-46,49-50,59H,9-12,21-35H2,1-6H3,(H,60,75)(H,61,76)(H,62,73)(H,63,74)(H,64,77)(H,65,78)(H,66,79)(H,67,80)(H,69,70)(H,71,72)/t38-,39-,44-,45+,46-,49-,50-/m0/s1
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| InChIKey |
LQBBFMZJMRESON-RSLLFPGHSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1385.489
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Polar area
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474.02
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Complexity
|
2902.323377
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xlogp Value
|
1.2152
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Heavy Count
|
95
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Rot Bonds
|
42
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Hbond acc
|
23
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Hbond Donor
|
11
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Each Antibody-drug Conjugate Related to This Linker