Linker Information
General Information of This Linker
| Linker ID |
LIN0PBSEQ
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
Phenoxy silyl linker 38
|
|||||
| Linker Type |
Reduction sensitive linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C39H60N6O14S2Si
|
|||||
| Isosmiles |
CC([Si](OC1=C(OC)C=C(CO)C=C1OC)(OCCOCC(N=N2)=CN2CCOCCOCCOCCNC(C3=CC(NS(C=C)(=O)=O)=CC(NS(C=C)(=O)=O)=C3)=O)C(C)C)C
|
|||||
| InChI |
InChI=1S/C39H60N6O14S2Si/c1-9-60(48,49)42-33-23-32(24-34(25-33)43-61(50,51)10-2)39(47)40-11-13-54-15-17-56-18-16-55-14-12-45-26-35(41-44-45)28-57-19-20-58-62(29(3)4,30(5)6)59-38-36(52-7)21-31(27-46)22-37(38)53-8/h9-10,21-26,29-30,42-43,46H,1-2,11-20,27-28H2,3-8H3,(H,40,47)
|
|||||
| InChIKey |
UJLVOPVFGBKDSB-UHFFFAOYSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
929.157
|
Polar area
|
246.22
|
||
|
Complexity
|
1935.794429
|
xlogp Value
|
3.9122
|
|||
|
Heavy Count
|
62
|
Rot Bonds
|
32
|
|||
|
Hbond acc
|
17
|
Hbond Donor
|
4
|
|||
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
39914224 Ate-38 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
8.01 nM
|
Positive PD-L1 expression (PD-L1+++/++) | ||
| Method Description |
The starting point of the small molecule drug was 500 nM, and the drug was diluted 5 times sequentially, for a total of eight concentration points. Cells were laid on 96-well plate at 4000 cells/well, cultured overnight and were added with diluted drugs, in the incubator for 72 h. All cells incubated with the drug were tested for cell viability using Cell Counting Kit-8 (CCK-8) kit (Meilunbio, Dalian, China).
Click to Show/Hide
|
||||
| In Vitro Model | Glioblastoma | U87 cells | CVCL_0022 | ||
References