Linker Information
General Information of This Linker
| Linker ID |
LIN0OWBMA
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| Linker Name |
Linker of ADC2-47
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C43H60N10O20
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| Isosmiles |
O=C(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)=O)=O)[C@@H](NC(CCNC(CNC(/C=C\C(O)=O)=O)=O)=O)CCC(NC[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]2CC(NC[C@@H]3[C@@H](O)[C@@H](O)[C@@H](O3)CC(N)=O)=O)=O
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| InChI |
InChI=1S/C43H60N10O20/c44-28(54)13-24-38(66)40(68)27(72-24)16-47-32(58)14-25-39(67)41(69)26(73-25)15-46-29(55)7-6-22(52-31(57)10-11-45-33(59)17-48-30(56)8-9-36(62)63)42(70)50-18-34(60)49-19-35(61)53-23(43(71)51-20-37(64)65)12-21-4-2-1-3-5-21/h1-5,8-9,22-27,38-41,66-69H,6-7,10-20H2,(H2,44,54)(H,45,59)(H,46,55)(H,47,58)(H,48,56)(H,49,60)(H,50,70)(H,51,71)(H,52,57)(H,53,61)(H,62,63)(H,64,65)/b9-8-/t22-,23-,24-,25-,26+,27+,38-,39-,40+,41+/m0/s1
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| InChIKey |
AUKNETQUEMDUSK-SJIHYODXSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1037.003
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Polar area
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478.97
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Complexity
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2083.695411
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xlogp Value
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-8.8483
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Heavy Count
|
73
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Rot Bonds
|
30
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Hbond acc
|
18
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Hbond Donor
|
16
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Each Antibody-drug Conjugate Related to This Linker