Linker Information
General Information of This Linker
| Linker ID |
LIN0OKNKN
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| Linker Name |
Linker of ADC2-40
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C34H46N8O16S
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| Isosmiles |
O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)=O)[C@@H](NC(CCNC(CNC(/C=C\C(O)=O)=O)=O)=O)CCC(NC(O2)[C@H](O)[C@H](O)[C@H]2CO)=O.[S]
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| InChI |
InChI=1S/C34H46N8O16.S/c43-17-21-30(54)31(55)34(58-21)42-23(45)7-6-19(40-24(46)10-11-35-25(47)13-36-22(44)8-9-28(50)51)32(56)38-14-26(48)37-15-27(49)41-20(33(57)39-16-29(52)53)12-18-4-2-1-3-5-18;/h1-5,8-9,19-21,30-31,34,43,54-55H,6-7,10-17H2,(H,35,47)(H,36,44)(H,37,48)(H,38,56)(H,39,57)(H,40,46)(H,41,49)(H,42,45)(H,50,51)(H,52,53);/b9-8-;/t19-,20-,21+,30+,31+,34?;/m0./s1
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| InChIKey |
UMQWJIMSVRAHIZ-DNICFCPHSA-N
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| Pharmaceutical Properties |
Molecule Weight
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854.849
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Polar area
|
377.32
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Complexity
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1597.569829
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xlogp Value
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-6.1212
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Heavy Count
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59
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Rot Bonds
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24
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Hbond acc
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14
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Hbond Donor
|
13
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Each Antibody-drug Conjugate Related to This Linker