Linker Information
General Information of This Linker
| Linker ID |
LIN0OKDVB
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| Linker Name |
CN119326907A Trastuzumab-GDP-D-P2/P4-P4-GGFG-Dxd Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C83H133N17O34
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| Isosmiles |
C=C(/C=C\C)C[C@H](NC(CNC(CNC(CCOCCOCCOCCOCC1=CN(N=N1)CCOCCOCCC(N[C@H](C(NC[C@H](O2)[C@@H](O)[C@@H](O)[C@H](O)[C@H]2O)=O)CCCCNC(CCOCCOCCOCCOCCN3C=C(N=N3)COCCOCCOCCOCCC(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O)C(NCC(O)=O)=O
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| InChI |
InChI=1S/C83H133N17O34/c1-3-9-59(2)46-64(81(117)90-53-75(109)110)93-73(107)51-87-71(105)49-85-68(102)14-21-121-28-33-127-38-40-130-42-44-132-57-61-55-99(97-95-61)18-24-124-30-26-123-23-16-70(104)92-63(80(116)89-48-66-77(113)78(114)79(115)83(119)134-66)12-7-8-17-84-67(101)13-20-120-27-32-126-36-37-129-35-31-125-25-19-100-56-62(96-98-100)58-133-45-43-131-41-39-128-34-29-122-22-15-69(103)86-50-72(106)88-52-74(108)94-65(82(118)91-54-76(111)112)47-60-10-5-4-6-11-60/h3-6,9-11,55-56,63-66,77-79,83,113-115,119H,2,7-8,12-54,57-58H2,1H3,(H,84,101)(H,85,102)(H,86,103)(H,87,105)(H,88,106)(H,89,116)(H,90,117)(H,91,118)(H,92,104)(H,93,107)(H,94,108)(H,109,110)(H,111,112)/b9-3-/t63-,64-,65-,66-,77+,78+,79-,83-/m0/s1
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| InChIKey |
HYDISNYOUXFICD-XWSOQBMHSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1913.062
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Polar area
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675.49
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Complexity
|
.
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xlogp Value
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-7.3489
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Heavy Count
|
134
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Rot Bonds
|
82
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Hbond acc
|
38
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Hbond Donor
|
17
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Each Antibody-drug Conjugate Related to This Linker