Linker Information
General Information of This Linker
| Linker ID |
LIN0OFVZZ
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
P5 (PEG12)-VA-PAB linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C49H79N4O20PS
|
|||||
| Isosmiles |
CC([C@H](NC(C1=CC=C(NP(/C=C\S)(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)=O)C=C1)=O)C(N[C@@H](C)C(NC2=CC=C(COC(O)=O)C=C2)=O)=O)C
|
|||||
| InChI |
InChI=1S/C49H79N4O20PS/c1-39(2)45(48(57)50-40(3)46(55)51-43-8-4-41(5-9-43)38-72-49(58)59)52-47(56)42-6-10-44(11-7-42)53-74(60,36-37-75)73-35-34-71-33-32-70-31-30-69-29-28-68-27-26-67-25-24-66-23-22-65-21-20-64-19-18-63-17-16-62-15-14-61-13-12-54/h4-11,36-37,39-40,45,54,75H,12-35,38H2,1-3H3,(H,50,57)(H,51,55)(H,52,56)(H,53,60)(H,58,59)/b37-36-/t40-,45-,74?/m0/s1
|
|||||
| InChIKey |
BBKGBKYVKODXDF-AVJHSAILSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
1107.22
|
Polar area
|
293.92
|
||
|
Complexity
|
1790.465957
|
xlogp Value
|
3.9765
|
|||
|
Heavy Count
|
75
|
Rot Bonds
|
48
|
|||
|
Hbond acc
|
20
|
Hbond Donor
|
7
|
|||
Each Antibody-drug Conjugate Related to This Linker