Linker Information
General Information of This Linker
| Linker ID |
LIN0OCQNL
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| Linker Name |
DBCO-PEG4-Gly (OH)
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C30H37N3O8
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| Isosmiles |
OC(NCCOCCOCCOCCOCCC(NCCC(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)=O)=O)=O
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| InChI |
InChI=1S/C30H37N3O8/c34-28(12-15-38-17-19-40-21-22-41-20-18-39-16-14-32-30(36)37)31-13-11-29(35)33-23-26-7-2-1-5-24(26)9-10-25-6-3-4-8-27(25)33/h1-8,32H,11-23H2,(H,31,34)(H,36,37)
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| InChIKey |
SKBQZLOOZPGGAO-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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567.639
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Polar area
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135.66
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Complexity
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1149.801051
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xlogp Value
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2.1634
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Heavy Count
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41
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Rot Bonds
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18
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Hbond acc
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7
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Hbond Donor
|
3
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
IN202417103159A D04-F404-LP30 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.043 nM
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Positive ROR1 expression (ROR1+++/++) | ||
| Method Description |
The cell killing EC5o and Span for RORI ADCs conjugated to different linker warheads at different DARs on RORI positive Ntera-2 cell and RORI negative MCF-7 cells
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| In Vitro Model | Embryonal carcinoma | Ntera-2 cells | CVCL_0034 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 10 nM | Negative ROR1 expression (ROR1-) | ||
| Method Description |
The cell killing EC5o and Span for RORI ADCs conjugated to different linker warheads at different DARs on RORI positive Ntera-2 cell and RORI negative MCF-7 cells
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| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
References