Linker Information
General Information of This Linker
| Linker ID |
LIN0OCPSV
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
CN110997010A ADC-31 linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C67H95N11O20S2
|
|||||
| Isosmiles |
CC([C@H](N(C)C(CCCCCN1C(CC(SCC(NC(C(NC(OCCOCCN2C(CCC2=O)=O)=O)CSC(CC3=O)C(N3CCCCCC(N(C)[C@H](C(N[C@@H](C)C(NC4=CC=C(CO)C=C4)=O)=O)C(C)C)=O)=O)=O)C(O)=O)C1=O)=O)=O)C(N[C@@H](C)C(NC5=CC=C(CO)C=C5)=O)=O)C
|
|||||
| InChI |
InChI=1S/C67H95N11O20S2/c1-39(2)57(62(90)68-41(5)59(87)70-45-21-17-43(35-79)18-22-45)74(7)51(81)15-11-9-13-27-77-55(85)33-49(64(77)92)99-37-47(73-67(96)98-32-31-97-30-29-76-53(83)25-26-54(76)84)61(89)72-48(66(94)95)38-100-50-34-56(86)78(65(50)93)28-14-10-12-16-52(82)75(8)58(40(3)4)63(91)69-42(6)60(88)71-46-23-19-44(36-80)20-24-46/h17-24,39-42,47-50,57-58,79-80H,9-16,25-38H2,1-8H3,(H,68,90)(H,69,91)(H,70,87)(H,71,88)(H,72,89)(H,73,96)(H,94,95)/t41-,42-,47?,48?,49?,50?,57-,58-/m0/s1
|
|||||
| InChIKey |
IZIFWGGVQCTBFL-NBRZXMEOSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
1438.688
|
Polar area
|
423.58
|
||
|
Complexity
|
3102.401918
|
xlogp Value
|
1.8958
|
|||
|
Heavy Count
|
100
|
Rot Bonds
|
42
|
|||
|
Hbond acc
|
21
|
Hbond Donor
|
9
|
|||
Each Antibody-drug Conjugate Related to This Linker