Linker Information
General Information of This Linker
| Linker ID |
LIN0OBBZG
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| Linker Name |
L13 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C187H340N18O83
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| Isosmiles |
CN(CC(C=C(NC([C@@H](NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCNC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN1C(C=CC1=O)=O)=O)CCC(NCC(N[C@@H](C(C)C)C(N[C@H](C(NC2=CC(CN(C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)C)=C(O)C=C2)=O)CCCNC(N)=O)=O)=O)=O)=O)=O)=O)CCCNC(N)=O)=O)C=C3)=C3O)C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O
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| InChI |
InChI=1S/C187H340N18O83/c1-158(2)177(182(221)199-164(9-7-23-191-184(188)223)180(219)196-162-11-14-167(206)160(153-162)156-203(5)186(225)193-26-34-232-42-50-240-58-66-248-74-80-254-86-91-259-95-99-263-103-107-267-111-115-271-119-123-275-127-131-279-135-139-283-143-147-287-151-149-285-145-141-281-137-133-277-129-125-273-121-117-269-113-109-265-105-101-261-97-93-257-89-84-252-78-71-245-63-55-237-47-39-229-31-21-175(214)215)201-171(210)20-30-228-38-46-236-54-62-244-69-73-247-65-57-239-49-41-231-33-25-190-179(218)166(198-170(209)19-29-227-37-45-235-53-61-243-70-77-251-83-88-256-82-76-250-68-60-242-52-44-234-36-28-205-173(212)17-18-174(205)213)13-16-169(208)195-155-172(211)202-178(159(3)4)183(222)200-165(10-8-24-192-185(189)224)181(220)197-163-12-15-168(207)161(154-163)157-204(6)187(226)194-27-35-233-43-51-241-59-67-249-75-81-255-87-92-260-96-100-264-104-108-268-112-116-272-120-124-276-128-132-280-136-140-284-144-148-288-152-150-286-146-142-282-138-134-278-130-126-274-122-118-270-114-110-266-106-102-262-98-94-258-90-85-253-79-72-246-64-56-238-48-40-230-32-22-176(216)217/h11-12,14-15,17-18,153-154,158-159,164-166,177-178,206-207H,7-10,13,16,19-152,155-157H2,1-6H3,(H,190,218)(H,193,225)(H,194,226)(H,195,208)(H,196,219)(H,197,220)(H,198,209)(H,199,221)(H,200,222)(H,201,210)(H,202,211)(H,214,215)(H,216,217)(H3,188,191,223)(H3,189,192,224)/t164-,165-,166-,177-,178-/m0/s1
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| InChIKey |
WAQHQIBUZMQZEW-LPLJZIKNSA-N
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| Pharmaceutical Properties |
Molecule Weight
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4168.82
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Polar area
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1161.52
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Complexity
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.
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xlogp Value
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-1.7128
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Heavy Count
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288
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Rot Bonds
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229
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Hbond acc
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81
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Hbond Donor
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19
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CD74 Milatuzumab DANAPAE152C S375C-P2-L13-P1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.217 nM
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High CD74 expression (CD74 +++) | ||
| Method Description |
CD74 Milatuzumab DANAPAE152C S375C-P2-L13-P1 was tested in EOL-1
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| In Vitro Model | Chronic eosinophilic leukemia | EoL-1 cells | CVCL_0258 | ||