Linker Information
General Information of This Linker
| Linker ID |
LIN0OADTV
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
EP4487874A1-9linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C49H70N10O19
|
|||||
| Isosmiles |
CC(C)[C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCNC([C@@H](N1C(C=CC1=O)=O)CNC([C@@H](O2)CCC2=O)=O)=O)=O)CC(N[C@@H](CCO3)C3=O)=O)=O)C(N[C@H](C(NC4=CC=C(CO)C=C4)=O)CCCNC(N)=O)=O
|
|||||
| InChI |
InChI=1S/C49H70N10O19/c1-29(2)42(47(70)57-32(4-3-15-52-49(50)72)43(66)54-31-7-5-30(28-60)6-8-31)58-44(67)34(26-38(62)55-33-13-18-77-48(33)71)56-37(61)14-17-73-20-22-75-24-25-76-23-21-74-19-16-51-45(68)35(59-39(63)10-11-40(59)64)27-53-46(69)36-9-12-41(65)78-36/h5-8,10-11,29,32-36,42,60H,3-4,9,12-28H2,1-2H3,(H,51,68)(H,53,69)(H,54,66)(H,55,62)(H,56,61)(H,57,70)(H,58,67)(H3,50,52,72)/t32-,33-,34-,35-,36-,42+/m0/s1
|
|||||
| InChIKey |
WHBVUZSUGIRXRU-CHHUGIBHSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
1103.15
|
Polar area
|
405.95
|
||
|
Complexity
|
2180.772904
|
xlogp Value
|
-3.8138
|
|||
|
Heavy Count
|
78
|
Rot Bonds
|
36
|
|||
|
Hbond acc
|
19
|
Hbond Donor
|
10
|
|||
Each Antibody-drug Conjugate Related to This Linker