Linker Information
General Information of This Linker
| Linker ID |
LIN0NWYFQ
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| Linker Name |
WO2024043319A1 Linker 20
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C29H32N4O9S2
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| Isosmiles |
NC(C[C@H](NC(CNC(CCOCCOCCN1C(C(SC2=CC=CC=C2)=C(SC3=CC=CC=C3)C1=O)=O)=O)=O)C(O)=O)=O
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| InChI |
InChI=1S/C29H32N4O9S2/c30-22(34)17-21(29(39)40)32-24(36)18-31-23(35)11-13-41-15-16-42-14-12-33-27(37)25(43-19-7-3-1-4-8-19)26(28(33)38)44-20-9-5-2-6-10-20/h1-10,21H,11-18H2,(H2,30,34)(H,31,35)(H,32,36)(H,39,40)/t21-/m0/s1
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| InChIKey |
ONKAZHOVNMRRMC-NRFANRHFSA-N
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| Pharmaceutical Properties |
Molecule Weight
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644.728
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Polar area
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194.43
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Complexity
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1249.107977
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xlogp Value
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1.1357
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Heavy Count
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44
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Rot Bonds
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19
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Hbond acc
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10
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
WO2024043319A1 20 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.035 nM
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Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||