Linker Information
General Information of This Linker
| Linker ID |
LIN0NTQOX
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|---|---|---|---|---|---|---|
| Linker Name |
ADCProductionexampleNo.8Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C47H71N10O20P
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| Isosmiles |
CC(C)[C@H](NC([C@H](CC(N[C@@H](CCO1)C1=O)=O)NC(CCOCCOCCOCCOCCNC([C@@H](N2C(C=CC2=O)=O)CNC(CCP(O)(O)=O)=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(CO)C=C3)=O)=O
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| InChI |
InChI=1S/C47H71N10O20P/c1-29(2)41(45(67)55-32(4-3-14-50-47(48)69)42(64)52-31-7-5-30(28-58)6-8-31)56-43(65)34(26-38(61)53-33-11-17-77-46(33)68)54-37(60)12-16-73-19-21-75-23-24-76-22-20-74-18-15-49-44(66)35(57-39(62)9-10-40(57)63)27-51-36(59)13-25-78(70,71)72/h5-10,29,32-35,41,58H,3-4,11-28H2,1-2H3,(H,49,66)(H,51,59)(H,52,64)(H,53,61)(H,54,60)(H,55,67)(H,56,65)(H3,48,50,69)(H2,70,71,72)/t32-,33-,34-,35-,41-/m0/s1
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| InChIKey |
MRUKAPSJIFLNQX-KRLSWSLDSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1127.109
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Polar area
|
437.18
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Complexity
|
2172.772904
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xlogp Value
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-3.9516
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Heavy Count
|
78
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Rot Bonds
|
38
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Hbond acc
|
18
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Hbond Donor
|
12
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Each Antibody-drug Conjugate Related to This Linker