Linker Information
General Information of This Linker
| Linker ID |
LIN0NTLUP
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| Linker Name |
BCN-GGFG linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C26H32N4O7
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| Isosmiles |
O=C(OC[C@H]1[C@@]2([H])CCC#CCC[C@]21[H])NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC3=CC=CC=C3)=O)=O
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| InChI |
InChI=1S/C26H32N4O7/c31-22(13-29-26(36)37-16-20-18-10-6-1-2-7-11-19(18)20)27-14-23(32)30-21(25(35)28-15-24(33)34)12-17-8-4-3-5-9-17/h3-5,8-9,18-21H,6-7,10-16H2,(H,27,31)(H,28,35)(H,29,36)(H,30,32)(H,33,34)/t18-,19+,20-,21-/m0/s1
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| InChIKey |
FMSYHICLFSVNAT-WOZUAGRISA-N
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| Pharmaceutical Properties |
Molecule Weight
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512.563
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Polar area
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162.93
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Complexity
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989.1131921
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xlogp Value
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0.1967
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Heavy Count
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37
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Rot Bonds
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12
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Hbond acc
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6
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP10 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
1.591 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 17% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||